MMP13 is a critical target gene during the progression of osteoarthritis

2013503 citationsJournal Articlegold Open Access

Authors

Meina Wang · Yale University

Erik R. Sampson · University of Rochester Medical Center

Hongting Jin · Zhejiang Chinese Medical University

Jia Li · Liaoning University of Traditional Chinese Medicine

Qiao Han Ke · Rush University Medical Center

Hee‐Jeong Im · Rush University Medical Center

Di Chen

Abstract

Mmp13 is critical for OA progression and pharmacologic inhibition of MMP13 is an effective strategy to decelerate articular cartilage loss in a murine model of injury-induced knee OA.

Topics & Keywords

Osteoarthritis Treatment and Mechanisms Protease and Inhibitor Mechanisms Bone Metabolism and Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis Research & Therapy

Volume 15, Issue 1, pp. R5-R5

DOI: 10.1186/ar4133

Field-Weighted Citation Impact: 17.14