Microevolution of<i>Mycobacterium tuberculosis</i>in a Tuberculosis Patient

201062 citationsJournal Articlegreen Open Access

Authors

Sahal Al‐Hajoj · King Faisal Specialist Hospital & Research Centre

Onno W. Akkerman · Medisch Spectrum Twente

Ida Parwati · Dr. Hasan Sadikin General Hospital

Saad al-Gamdi · Hera General Hospital

Zeaur Rahim · International Centre for Diarrhoeal Disease Research

Dick van Soolingen · National Institute for Public Health and the Environment

Jakko van Ingen

Abstract

Five Mycobacterium tuberculosis isolates were obtained from three body sites from a Dutch patient. The isolates displayed a single genotype by 24-locus MIRU-VNTR typing (except for a single locus not amplified from one isolate) but were differentiated by small variations in IS6110 fingerprints, spoligotypes, 6 hypervariable MIRU-VNTR loci, and/or DiversiLab profiles, revealing patterns of microevolution in a clonal infection.

Topics & Keywords

Tuberculosis Research and Epidemiology Mycobacterium research and diagnosis Diagnosis and treatment of tuberculosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Microbiology

Volume 48, Issue 10, pp. 3813-3816

DOI: 10.1128/jcm.00556-10

Field-Weighted Citation Impact: 3.06