Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity

2011748 citationsJournal Articlegreen Open Access

Authors

Keith M. Godfrey

Allan Sheppard · AgResearch

Peter D. Gluckman · University of Auckland

Karen A. Lillycrop

Graham C. Burdge

Cameron McLean · AgResearch

Joanne Rodford

J.L. Slater-Jefferies

Emma Garratt

Sarah Crozier

Abstract

Our findings suggest a substantial component of metabolic disease risk has a prenatal developmental basis. Perinatal epigenetic analysis may have utility in identifying individual vulnerability to later obesity and metabolic disease.

Topics & Keywords

Birth, Development, and Health Epigenetics and DNA Methylation Gestational Diabetes Research and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 60, Issue 5, pp. 1528-1534

DOI: 10.2337/db10-0979

Field-Weighted Citation Impact: 116.23