The Neural Basis of Addiction: A Pathology of Motivation and Choice

20052,765 citationsReview

Authors

Peter W. Kalivas · Medical University of South Carolina

Nora D. Volkow · National Institute on Drug Abuse

Abstract

Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatergic drive in response to drug-associated stimuli.

Topics & Keywords

Neurotransmitter Receptor Influence on Behavior Receptor Mechanisms and Signaling Neuroscience and Neuropharmacology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Psychiatry

Volume 162, Issue 8, pp. 1403-1413

DOI: 10.1176/appi.ajp.162.8.1403

Field-Weighted Citation Impact: 45.96