The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

2013197 citationsJournal Articlegold Open Access

Authors

Lauren Stutzbach · University of Pennsylvania

Sharon X. Xie · University of Pennsylvania

Adam C. Naj · University of Pennsylvania

Roger L. Albin · University of Michigan

Sid Gilman · University of Michigan

PSP Genetics Study Group · Institute for Neurodegenerative Disorders

Virginia M.‐Y. Lee ·

Abstract

The UPR is activated in disease affected regions in PSP and the genetic evidence shows that this activation increases risk for PSP and is not a protective response.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Endoplasmic Reticulum Stress and Disease Alzheimer's disease research and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Acta Neuropathologica Communications

Volume 1, Issue 1, pp. 31-31

DOI: 10.1186/2051-5960-1-31

Field-Weighted Citation Impact: 6.13