Genetic Associations with Valvular Calcification and Aortic Stenosis

2013958 citationsReviewbronze Open Access

Authors

George Thanassoulis · National Institutes of Health

Catherine Y. Campbell · Johns Hopkins University

David S. Owens · University of Washington

J. G. Smith · Broad Institute

Albert V. Smith · University of Iceland

Gina M. Peloso · National Institutes of Health

Kathleen F. Kerr ·

Abstract

Genetic variation in the LPA locus, mediated by Lp(a) levels, is associated with aortic-valve calcification across multiple ethnic groups and with incident clinical aortic stenosis. (Funded by the National Heart, Lung, and Blood Institute and others.).

Topics & Keywords

Cardiac Valve Diseases and Treatments Aortic Thrombus and Embolism Hypertrophic osteoarthropathy and related conditions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 368, Issue 6, pp. 503-512

DOI: 10.1056/nejmoa1109034

Field-Weighted Citation Impact: 40.47