miR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs

2014103 citationsJournal Articlegold Open Access

Authors

Cheng‐Gong Liao · Urumqi General Hospital of PLA

Ling‐Min Kong · Air Force Medical University

Ping Zhou · Urumqi General Hospital of PLA

Xiuli Yang · Urumqi General Hospital of PLA

Jianguo Huang · Urumqi General Hospital of PLA

Helong Zhang · Air Force Medical University

Ning Lü ·

Abstract

Our results suggested that miR-10b was overexpressed in HCC and promoted HCC cell migration and invasion through the HOXD10/ RhoC/ uPAR/ MMPs pathway which may provide a novel bio-target for HCC therapy.

Topics & Keywords

MicroRNA in disease regulation Circular RNAs in diseases Cancer-related molecular mechanisms research

Publication Details

Published in: Journal of Translational Medicine

Volume 12, Issue 1, pp. 234-234

DOI: 10.1186/s12967-014-0234-x

Field-Weighted Citation Impact: 3.44

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miR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs

Authors

Abstract

Topics & Keywords

Publication Details