Genome-Wide Meta-Analyses of Plasma Renin Activity and Concentration Reveal Association With the Kininogen 1 and Prekallikrein Genes

201428 citationsReviewbronze Open Access

Authors

Wolfgang Lieb · Kiel University

Ming‐Huei Chen · Boston University

Alexander Teumer · Universitätsmedizin Greifswald

Rudolf A. de Boer

Honghuang Lin

Ervin R. Fox · University of Mississippi Medical Center

Solomon K. Musani · University of Mississippi Medical Center

James G. Wilson

Abstract

We identified 2 genetic loci (kininogen 1 and kallikrein B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein-kinin system and the RAAS.

Topics & Keywords

Renin-Angiotensin System Studies Hormonal Regulation and Hypertension Heart Failure Treatment and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Cardiovascular Genetics

Volume 8, Issue 1, pp. 131-140

DOI: 10.1161/circgenetics.114.000613

Field-Weighted Citation Impact: 1.58