Strategies for Heterocyclic Construction via Novel Multicomponent Reactions Based on Isocyanides and Nucleophilic Carbenes

2003796 citationsJournal Article

Authors

Vijay Nair · National Institute for Interdisciplinary Science and Technology

C. Rajesh · Institute of Minerals and Materials Technology

A. U. Vinod · Institute of Minerals and Materials Technology

S. Bindu · Institute of Minerals and Materials Technology

A. R. Sreekanth · Advanced Materials and Processes Research Institute

Joseph Swaroop Mathen · National Institute for Interdisciplinary Science and Technology

Abstract

This Account focuses mainly on our recent endeavors in the area of multicomponent reactions (MCRs) involving zwitterionic species generated by the addition of isocyanides and nucleophilic carbenes such as dimethoxycarbene and N-heterocyclic carbenes to activated alkynes. The strategy employed encompasses the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles. The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance.

Topics & Keywords

Multicomponent Synthesis of Heterocycles Click Chemistry and Applications Catalytic C–H Functionalization Methods

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Accounts of Chemical Research

Volume 36, Issue 12, pp. 899-907

DOI: 10.1021/ar020258p

Field-Weighted Citation Impact: 17.10