Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

19951,052 citationsJournal Articlebronze Open Access

Authors

Crystal L. Mackall · National Institutes of Health

Thomas A. Fleisher · National Institutes of Health Clinical Center

Margaret R. Brown · National Institutes of Health Clinical Center

Mary P. Andrich · National Institutes of Health Clinical Center

Clara C. Chen · National Institutes of Health Clinical Center

Irwin M. Feuerstein · Unifor

Marc E. Horowitz

Abstract

Thymus-dependent regeneration of CD4+ T lymphocytes occurs primarily in children, whereas even young adults have deficiencies in this pathway. Our results suggest that rapid T-cell regeneration requires residual thymic function in patients receiving high-dose chemotherapy.

Topics & Keywords

Immunotherapy and Immune Responses Immune Cell Function and Interaction Hematopoietic Stem Cell Transplantation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 332, Issue 3, pp. 143-149

DOI: 10.1056/nejm199501193320303

Field-Weighted Citation Impact: 19.12