Organic Cation Transporter Variation and Response to Smoking Cessation Therapies

201424 citationsJournal Articlebronze Open Access

Authors

Andrew W. Bergen · SRI International

Harold S. Javitz · SRI International

Ruth E. Krasnow · SRI International

M. Michel · SRI International

Denise Nishita · SRI International

David V. Conti · University of Southern California

Christopher K. Edlund ·

Abstract

The functional OCT2 Ser270Ala polymorphism is nominally statistically significantly associated with abstinence among European-ancestry treatment-seeking smokers after adjustments for pharmacotherapy, demographics, population genetics, and without adjustment for multiple testing of 7 SNPs. Replication of these preliminary findings in additional randomized controlled trials of smoking cessation therapies and from multiple continental populations would describe another pharmacogenetic role for SLC22A2/OCT2.

Topics & Keywords

Peroxisome Proliferator-Activated Receptors Fatty Acid Research and Health Phytoestrogen effects and research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Nicotine & Tobacco Research

Volume 16, Issue 12, pp. 1638-1646

DOI: 10.1093/ntr/ntu161

Field-Weighted Citation Impact: 1.14