Mitochondrial OPA1, apoptosis, and heart failure

2009405 citationsJournal Articlebronze Open Access

Authors

Le Chen · University of California, Davis

Qizhi Gong · University of California, Davis

James P. Stice · University of California, Davis

Anne A. Knowlton · Northern California Research

Abstract

This is the first report, to our knowledge, of changes in mitochondrial fusion/fission proteins in cardiovascular disease. These changes have implications for mitochondrial function and apoptosis, contributing to the cell loss which is part of the downward progression of the failing heart.

Topics & Keywords

Mitochondrial Function and Pathology ATP Synthase and ATPases Research Metabolism and Genetic Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cardiovascular Research

Volume 84, Issue 1, pp. 91-99

DOI: 10.1093/cvr/cvp181

Field-Weighted Citation Impact: 7.53