A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer

2015286 citationsJournal Articlebronze Open Access

Authors

Gerard A. Silvestri · Medical University of South Carolina

Anil Vachani · University of Pennsylvania

Duncan Whitney · Veracyte (United States)

Michael Elashoff

Kate Smith · Diagnostics For All

J. Scott Ferguson · University of Wisconsin–Madison

E. Parsons · Diagnostics For All

Abstract

The gene-expression classifier improved the diagnostic performance of bronchoscopy for the detection of lung cancer. In intermediate-risk patients with a nondiagnostic bronchoscopic examination, a negative classifier score provides support for a more conservative diagnostic approach. (Funded by Allegro Diagnostics and others; AEGIS-1 and AEGIS-2 ClinicalTrials.gov numbers, NCT01309087 and NCT00746759.).

Topics & Keywords

Lung Cancer Diagnosis and Treatment Lung Cancer Treatments and Mutations Tracheal and airway disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 373, Issue 3, pp. 243-251

DOI: 10.1056/nejmoa1504601

Field-Weighted Citation Impact: 26.55