Clinical and laboratory features of fatal rapidly progressive interstitial lung disease associated with juvenile dermatomyositis

2014141 citationsJournal Articlebronze Open Access

Authors

Norihiro Kobayashi · Shinshu University

Shunichiro Takezaki · Shinshu University

Ichiro Kobayashi · Keio University

Naomi Iwata · Kobe Children's Hospital

Mitsuharu Mori · Kanagawa Children's Medical Center

Kozo Nagai · Hokkaido University

Naoko Nakano ·

Abstract

High serum levels of IL-18, KL-6, ferritin and anti-MDA5 antibodies (e.g. >200 units by ELISA) are associated with RP-ILD. These can be used as an indication for early intensive treatment. Both alveolar macrophages and autoimmunity to MDA5 are possibly involved in the development of RP-ILD associated with JDM.

Topics & Keywords

Inflammatory Myopathies and Dermatomyositis Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Eosinophilic Disorders and Syndromes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Lara D. Veeken

Volume 54, Issue 5, pp. 784-791

DOI: 10.1093/rheumatology/keu385

Field-Weighted Citation Impact: 5.14