Mucus Clearance and Lung Function in Cystic Fibrosis with Hypertonic Saline

2006686 citationsJournal Article

Authors

Scott H. Donaldson · Donaldson (United States)

William D. Bennett · Center for Environmental Health

Kirby L. Zeman · Center for Environmental Health

Michael R. Knowles · University of North Carolina at Chapel Hill

Robert Tarran · University of North Carolina at Chapel Hill

Richard C. Boucher · University of North Carolina at Chapel Hill

Abstract

In patients with cystic fibrosis, inhalation of hypertonic saline produced a sustained acceleration of mucus clearance and improved lung function. This treatment may protect the lung from insults that reduce mucus clearance and produce lung disease.

Topics & Keywords

Cystic Fibrosis Research Advances Respiratory Support and Mechanisms Neonatal Respiratory Health Research

Publication Details

Published in: New England Journal of Medicine

Volume 354, Issue 3, pp. 241-250

DOI: 10.1056/nejmoa043891

Field-Weighted Citation Impact: 39.54

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Mucus Clearance and Lung Function in Cystic Fibrosis with Hypertonic Saline

Authors

Abstract

Topics & Keywords

Publication Details