Lifetime Prevalence, Age of Risk, and Genetic Relationships of Comorbid Psychiatric Disorders in Tourette Syndrome

2015741 citationsJournal Articlebronze Open Access

Authors

Matthew E. Hirschtritt · University of California, San Francisco

Paul C. Lee · Center for Human Genetics

David L. Pauls · Center for Human Genetics

Yves Dion · Université de Montréal

Marco A. Grados · Johns Hopkins University

Cornelia Illmann · Center for Human Genetics

Robert A. King

Abstract

This study is, to our knowledge, the most comprehensive of its kind. It confirms the belief that psychiatric comorbidities are common among individuals with TS, demonstrates that most comorbidities begin early in life, and indicates that certain comorbidities may be mediated by the presence of comorbid OCD or ADHD. In addition, genetic analyses suggest that some comorbidities may be more biologically related to OCD and/or ADHD rather than to TS.

Topics & Keywords

Obsessive-Compulsive Spectrum Disorders Autism Spectrum Disorder Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Psychiatry

Volume 72, Issue 4, pp. 325-325

DOI: 10.1001/jamapsychiatry.2014.2650

Field-Weighted Citation Impact: 58.20