A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

2013522 citationsJournal Articlegold Open Access

Authors

Michelle M. Simon · Medical Research Council

Simon Greenaway · Mary Lyon Centre at MRC Harwell

Jacqueline K. White · Wellcome Sanger Institute

Helmut Fuchs · Helmholtz Zentrum München

Valérie Gailus‐Durner · Helmholtz Zentrum München

Sara Wells · Medical Research Council

Tania Sorg

Abstract

Comparison of C57BL/6J and C57BL/6N demonstrates a range of phenotypic differences that have the potential to impact upon penetrance and expressivity of mutational effects in these strains. Moreover, the sequence variants we identify provide a set of candidate genes for the phenotypic differences observed between the two strains.

Topics & Keywords

Genetic Mapping and Diversity in Plants and Animals Bioinformatics and Genomic Networks Genomics and Chromatin Dynamics

UN Sustainable Development Goals

Partnerships for the goals

Publication Details

Published in: Genome biology

Volume 14, Issue 7, pp. R82-R82

DOI: 10.1186/gb-2013-14-7-r82

Field-Weighted Citation Impact: 20.17