Diastolic Heart Failure — Abnormalities in Active Relaxation and Passive Stiffness of the Left Ventricle

20041,527 citationsJournal Articlebronze Open Access

Authors

Michael R. Zile · Medical University of South Carolina

William H. Gaasch · University of Massachusetts Chan Medical School

Abstract

Patients with heart failure and a normal ejection fraction have significant abnormalities in active relaxation and passive stiffness. In these patients, the pathophysiological cause of elevated diastolic pressures and heart failure is abnormal diastolic function.

Topics & Keywords

Cardiovascular Function and Risk Factors Cardiomyopathy and Myosin Studies Cardiac electrophysiology and arrhythmias

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 350, Issue 19, pp. 1953-1959

DOI: 10.1056/nejmoa032566

Field-Weighted Citation Impact: 39.50