A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

20063,706 citationsJournal Articlebronze Open Access

Authors

Carlos A. Zarate · National Institute of Mental Health

Jaskaran Singh

Abstract

Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week.

Topics & Keywords

Treatment of Major Depression Tryptophan and brain disorders Neurotransmitter Receptor Influence on Behavior

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of General Psychiatry

Volume 63, Issue 8, pp. 856-856

DOI: 10.1001/archpsyc.63.8.856

Field-Weighted Citation Impact: 54.98