Photochemical Inactivation of Bacteria and HIV in Buffy–Coat–Derived Platelet Concentrates under Conditions That Preserve in vitro Platelet Function

PCT with 150 microM S-59 and a 3 J/cm(2) UVA treatment does not adversely affect in vitro properties of BC PCs stored at 22 degrees C for 7 days. The PCT process inactivated bacteria and HIV-1 inoculated into the BC PCs. These results extend the earlier reported efficacy of PCT apheresis PCs to BC PCs.