The Impact of Childhood Obesity on Inflammation, Innate Immune Cell Frequency, and Metabolic MicroRNA Expression

2013105 citationsJournal Articlebronze Open Access

Authors

Eirin Carolan · St. Vincent's University Hospital

Andrew E. Hogan · National Children’s Research Centre

Michelle Corrigan · St. Vincent's University Hospital

Gadintshware Gaotswe · University College Dublin

Jeff Connell · St. Vincent's University Hospital

Niamh H. Foley · Trinity College Dublin

Luke O'neill

Abstract

Childhood obesity is associated with changes in immune cell frequency, inflammatory environment, and regulation of metabolic gene expression. These changes have been causally linked to the onset of metabolic disease in adulthood and suggest the future trajectory of obese children to the development of type 2 diabetes mellitus and premature cardiovascular disease.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Immune Cell Function and Interaction MicroRNA in disease regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 99, Issue 3, pp. E474-E478

DOI: 10.1210/jc.2013-3529

Field-Weighted Citation Impact: 5.09