Silymarin improved 6-OHDA-induced motor impairment in hemi-parkisonian rats: behavioral and molecular study

201452 citationsJournal Articlehybrid Open Access

Authors

Rasool Haddadi · Tabriz University of Medical Sciences

Alireza Mohajjel Nayebi · Tabriz University of Medical Sciences

Safar Farajniya · Tabriz University of Medical Sciences

Shahla Eyvari Brooshghalan · Tabriz University of Medical Sciences

Abstract

We found that pre-treatment with silymarin could improve 6-OHDA-induced motor imbalance by attenuating brain lipid per-oxidation as well as CSF level of IL-1β as a pro-inflammatory cytokine. We suggest a potential prophylactic effect for silymarin in PD. However, further clinical trial studies should be carried out to prove this hypothesis.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Cholinesterase and Neurodegenerative Diseases Aluminum toxicity and tolerance in plants and animals

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: DARU Journal of Pharmaceutical Sciences

Volume 22, Issue 1, pp. 38-38

DOI: 10.1186/2008-2231-22-38

Field-Weighted Citation Impact: 2.57