Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements

201480 citationsJournal Articlegold Open Access

Authors

Tsuyoshi Inoue · The University of Tokyo

Takahide Kohro · The University of Tokyo

Toshiya Tanaka · The University of Tokyo

Yasuharu Kanki · The University of Tokyo

Guoliang Li · Jackson Laboratory

Huay-Mei Poh · Genome Institute of Singapore

Imari Mimura ·

Abstract

To the best of our knowledge, this is the first report that two different transcription factors cooperate in transcriptional regulation in a synergistic fashion through conformational change of their common target genes.

Topics & Keywords

Lipid metabolism and disorders Cancer-related molecular mechanisms research Peroxisome Proliferator-Activated Receptors

Publication Details

Published in: Genome biology

Volume 15, Issue 4, pp. R63-R63

DOI: 10.1186/gb-2014-15-4-r63

Field-Weighted Citation Impact: 3.75

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Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements

Authors

Abstract

Topics & Keywords

Publication Details