Germline Genetic Contributions to Risk for Esophageal Adenocarcinoma, Barrett's Esophagus, and Gastroesophageal Reflux

201397 citationsJournal Articlebronze Open Access

Authors

Weronica E. Ek · QIMR Berghofer Medical Research Institute

D. M. Levine · Karolinska Institutet

Mauro D’Amato · Karolinska Institutet

Nancy L. Pedersen · Karolinska Institutet

Patrik K. E. Magnusson · Karolinska Institutet

Francesca Bresso · Karolinska Institutet

L. E. Onstad ·

Abstract

We have demonstrated that risk to BE and EA is influenced by many germline genetic variants of small effect and that shared polygenic effects contribute to risk of these two diseases.

Topics & Keywords

Helicobacter pylori-related gastroenterology studies Esophageal Cancer Research and Treatment Gastroesophageal reflux and treatments

UN Sustainable Development Goals

No poverty

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 105, Issue 22, pp. 1711-1718

DOI: 10.1093/jnci/djt303

Field-Weighted Citation Impact: 14.82