Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease

2011276 citationsJournal Articlehybrid Open Access

Authors

Qingjian Wang · FibroGen (United States)

William R. Usinger · FibroGen (United States)

Blake Nichols · FibroGen (United States)

Julia Gray · FibroGen (United States)

Leon Xu · FibroGen (United States)

Todd Seeley · FibroGen (United States)

Mitch Brenner ·

Abstract

Cooperative interactions between CTGF and TGF-β signaling are required to elicit overt tissue fibrosis. This interdependence and the observed anti-fibrotic effects of FG-3019 indicate that anti-CTGF therapy may provide therapeutic benefit in different forms of fibroproliferative disease.

Topics & Keywords

Connective Tissue Growth Factor Research Systemic Sclerosis and Related Diseases Connective tissue disorders research

Publication Details

Published in: Fibrogenesis & Tissue Repair

Volume 4, Issue 1, pp. 4-4

DOI: 10.1186/1755-1536-4-4

Field-Weighted Citation Impact: 10.63

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Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease

Authors

Abstract

Topics & Keywords

Publication Details