Intramyocardial, Autologous CD34+ Cell Therapy for Refractory Angina

2011488 citationsJournal Articlebronze Open Access

Authors

Douglas W. Losordo · University of Florida

Timothy D. Henry · Mayo Clinic in Arizona

Charles J. Davidson · Angiogenesis Foundation

Joon Sup Lee · Abbott Northwestern Hospital

Marco A. Costa · Mayo Clinic in Arizona

Theodore A. Bass · Clinical Research Institute

Farrell O. Mendelsohn

Abstract

Patients with refractory angina who received intramyocardial injections of autologous CD34+ cells (10(5) cells/kg) experienced significant improvements in angina frequency and exercise tolerance. The cell-mobilization and -collection procedures were associated with cardiac enzyme elevations, which will be addressed in future studies.

Topics & Keywords

Coronary Interventions and Diagnostics Cardiac Fibrosis and Remodeling Angiogenesis and VEGF in Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 109, Issue 4, pp. 428-436

DOI: 10.1161/circresaha.111.245993

Field-Weighted Citation Impact: 53.30