Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT

2014136 citationsJournal Articlebronze Open Access

Authors

Gisela Henriques · London School of Hygiene & Tropical Medicine

Rachel Hallett · London School of Hygiene & Tropical Medicine

Khalid B. Beshir · London School of Hygiene & Tropical Medicine

Nahla B. Gadalla · London School of Hygiene & Tropical Medicine

Rachel Johnson · London School of Hygiene & Tropical Medicine

Rebekah Burrow · London School of Hygiene & Tropical Medicine

Abstract

Among treated children in western Kenya, certain P. falciparum genotypes defined at pfcrt, pfmdr1, pfap2mu, and pfubp1 more often survive ACT at the submicroscopic level, and contribute to onward transmission and subsequent patent recrudescence.

Topics & Keywords

Malaria Research and Control Parasites and Host Interactions Computational Drug Discovery Methods

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 210, Issue 12, pp. 2001-2008

DOI: 10.1093/infdis/jiu358

Field-Weighted Citation Impact: 8.36