Strain-promoted double-click reaction for chemical modification of azido-biomolecules

2010108 citationsJournal Article

Authors

Isao Kii · Tokyo Institute of Technology

Akira Shiraishi · Tokyo Institute of Technology

Toshiyuki Hiramatsu · Japan Science and Technology Agency

Takeshi Matsushita · JNC (Japan)

Hidehiro Uekusa · Tokyo Institute of Technology

Suguru Yoshida · Tokyo Medical and Dental University

Makoto Yamamoto

Abstract

The strain-promoted "double-click" (SPDC) reaction using Sondheimer diyne, a novel convergent method conjugating three molecules spontaneously, has enabled us to readily modify an azido-biomolecule with a small reporter azido-molecule.

Topics & Keywords

Click Chemistry and Applications Monoclonal and Polyclonal Antibodies Research Chemical Synthesis and Analysis

Publication Details

Published in: Organic & Biomolecular Chemistry

Volume 8, Issue 18, pp. 4051-4051

DOI: 10.1039/c0ob00003e

Field-Weighted Citation Impact: 2.48

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Strain-promoted double-click reaction for chemical modification of azido-biomolecules

Authors

Abstract

Topics & Keywords

Publication Details