Molecular and Pharmacological Determinants of the Therapeutic Response to Artemether-Lumefantrine in Multidrug-Resistant Plasmodium falciparum Malaria

2006315 citationsJournal Articlebronze Open Access

Authors

Ric N. Price · John Radcliffe Hospital

Anne‐Catrin Uhlemann · University of London

Michèle van Vugt · Shoklo Malaria Research Unit

Al Brockman · Shoklo Malaria Research Unit

Robert Hutagalung · Shoklo Malaria Research Unit

Shalini Nair · Texas Biomedical Research Institute

Daniel A Nash

Abstract

The lumefantrine plasma concentration profile is the main determinant of efficacy of artemether-lumefantrine. Amplification in pfmdr1 determines lumefantrine susceptibility and, therefore, treatment responses when plasma lumefantrine levels are subtherapeutic.

Topics & Keywords

Malaria Research and Control Computational Drug Discovery Methods Drug-Induced Hepatotoxicity and Protection

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Infectious Diseases

Volume 42, Issue 11, pp. 1570-1577

DOI: 10.1086/503423

Field-Weighted Citation Impact: 20.60