Increased Cytosine DNA-Methyltransferase Activity During Colon Cancer Progression

1993313 citationsJournal Article

Authors

Jean‐Pierre J. Issa · Johns Hopkins University

Paula M. Vertino · Johns Hopkins University

Jindao Wu · Johns Hopkins University

Sudha Sazawal · Johns Hopkins University

P Celano · Johns Hopkins University

Barry D. Nelkin · Johns Hopkins University

Stanley R. Hamilton ·

Abstract

Further studies are needed to determine whether this abnormal methylation capacity plays a role in establishing the abnormal DNA methylation patterns seen in human malignancies.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 85, Issue 15, pp. 1235-1240

DOI: 10.1093/jnci/85.15.1235

Field-Weighted Citation Impact: 3.01