Airway Wall Thickening and Emphysema Show Independent Familial Aggregation in Chronic Obstructive Pulmonary Disease

2008321 citationsJournal Article

Authors

Bipen D. Patel · University of Cambridge

Harvey O. Coxson · University of British Columbia

Sreekumar Pillai · Research Triangle Park Foundation

Àlvar Agustí · Centro de Investigación Biomédica en Red de Enfermedades Respiratorias

Peter M.A. Calverley · University of Liverpool

Claudio F. Donner · Istituti Clinici Scientifici Maugeri

Barry J. Make

Abstract

Airway wall thickening and emphysema make independent contributions to airflow obstruction in COPD. These phenotypes show independent aggregation within families of individuals with COPD, suggesting that different genetic factors influence these disease processes.

Topics & Keywords

Chronic Obstructive Pulmonary Disease (COPD) Research Asthma and respiratory diseases Respiratory Support and Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 178, Issue 5, pp. 500-505

DOI: 10.1164/rccm.200801-059oc

Field-Weighted Citation Impact: 24.77