Region- and Type-Specific Induction of Matrix Metalloproteinases in Post–Myocardial Infarction Remodeling

2003198 citationsJournal Article

Authors

Eric Wilson · Tamil Nadu Dr. M.G.R. Medical University

Sina L. Moainie · Tamil Nadu Dr. M.G.R. Medical University

Julia M. Baskin · Tamil Nadu Dr. M.G.R. Medical University

Abigail S. Lowry · Tamil Nadu Dr. M.G.R. Medical University

Anne M. Deschamps · Tamil Nadu Dr. M.G.R. Medical University

Rupak Mukherjee · Tamil Nadu Dr. M.G.R. Medical University

T. Sloane Guy

Abstract

The unique findings of this study were 2-fold. First, changes in regional geometry after MI were associated with changes in MMP levels. Second, a region-specific portfolio of MMPs was induced after MI and was accompanied by a decline in TIMP levels, indicative of a loss of MMP inhibitory control. Targeting the regional imbalance between specific MMPs and TIMPs within the post-MI myocardium holds therapeutic potential.

Topics & Keywords

Cardiac Fibrosis and Remodeling Signaling Pathways in Disease Protease and Inhibitor Mechanisms

Publication Details

Published in: Circulation

Volume 107, Issue 22, pp. 2857-2863

DOI: 10.1161/01.cir.0000068375.40887.fa

Field-Weighted Citation Impact: 11.34

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Region- and Type-Specific Induction of Matrix Metalloproteinases in Post–Myocardial Infarction Remodeling

Authors

Abstract

Topics & Keywords

Publication Details