Preserving biological heterogeneity with a permuted surrogate variable analysis for genomics batch correction

2014140 citationsJournal Articlebronze Open Access

Authors

Hilary S. Parker · Sidney Kimmel Comprehensive Cancer Center

Jeffrey T. Leek · Genetika

Alexander V. Favorov · Johns Hopkins University

Michael Considine · Vavilov Institute of General Genetics

Xiaoxin Xia · Johns Hopkins University

Sameer Chavan · Johns Hopkins University

Christine H. Chung

Abstract

All analyses were performed using R version 2.15.0. The code and data used to generate the results of this manuscript is available from https://sourceforge.net/projects/psva.

Topics & Keywords

Molecular Biology Techniques and Applications Gene expression and cancer classification Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Partnerships for the goals

Publication Details

Published in: Bioinformatics

Volume 30, Issue 19, pp. 2757-2763

DOI: 10.1093/bioinformatics/btu375

Field-Weighted Citation Impact: 2.70