Glomerular Hyperfiltration and Renal Disease Progression in Type 2 Diabetes

2012314 citationsJournal Articlehybrid Open Access

Authors

Piero Ruggenenti · Mario Negri Institute for Pharmacological Research

Esteban Porrini · Mario Negri Institute for Pharmacological Research

Flavio Gaspari · Mario Negri Institute for Pharmacological Research

Nicola Motterlini · Mario Negri Institute for Pharmacological Research

Antonio Cannatà · Mario Negri Institute for Pharmacological Research

Fabiola Carrara · Mario Negri Institute for Pharmacological Research

Abstract

Despite intensified treatment, patients with type 2 diabetes have a fast GFR decline. Hyperfiltration affects a subgroup of patients and may contribute to renal function loss and nephropathy onset or progression. Whether amelioration of hyperfiltration is renoprotective is worth investigating.

Topics & Keywords

Chronic Kidney Disease and Diabetes Blood Pressure and Hypertension Studies Diabetes Treatment and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes Care

Volume 35, Issue 10, pp. 2061-2068

DOI: 10.2337/dc11-2189

Field-Weighted Citation Impact: 11.65