Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression

2001770 citationsJournal Articlebronze Open Access

Authors

David G. Burbee · The University of Texas Southwestern Medical Center

Éva Forgács · The University of Texas Southwestern Medical Center

Sabine Zöchbauer‐Müller · The University of Texas Southwestern Medical Center

Latha Shivakumar · The University of Texas Southwestern Medical Center

Kwun M. Fong

Bo Gao

Dwight E. Randle · The University of Texas Southwestern Medical Center

Abstract

RASSF1A is a potential tumor suppressor gene that undergoes epigenetic inactivation in lung and breast cancers through hypermethylation of its promoter region.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 93, Issue 9, pp. 691-699

DOI: 10.1093/jnci/93.9.691

Field-Weighted Citation Impact: 25.68