Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis

2005480 citationsJournal Articlegreen Open Access

Authors

Scott P. Fraser · Imperial College London

James K.J. Diss · Imperial College London

Athina‐Myrto Chioni · Imperial College London

Maria E. Mycielska · Imperial College London

Huiyan Pan · Imperial College London

Rezan Fahrioglu Yamaci · Boğaziçi University

Filippo Pani ·

Abstract

Up-regulation of neonatal Na(v)1.5 occurs as an integral part of the metastatic process in human breast cancer and could serve both as a novel marker of the metastatic phenotype and a therapeutic target.

Topics & Keywords

Ion channel regulation and function Ion Transport and Channel Regulation Planarian Biology and Electrostimulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 11, Issue 15, pp. 5381-5389

DOI: 10.1158/1078-0432.ccr-05-0327

Field-Weighted Citation Impact: 5.42