Paraneoplastic anti– <i>N</i> ‐methyl‐ <scp>D</scp> ‐aspartate receptor encephalitis associated with ovarian teratoma

20072,445 citationsJournal Article

Authors

Josep Dalmau · University of Pennsylvania

Erdem Tüzün · University of Pennsylvania

Haiyan Wu · University of Pennsylvania

Jaime Masjuan · Hospital Universitario Ramón y Cajal

Jeffrey Rossi · University of Pennsylvania

Alfredo Voloschin · Augusta University

Joachim M. Baehring ·

Abstract

Antibodies to NR2B- and NR2A-containing heteromers of the NMDAR associate with a severe but treatment-responsive encephalitis. Our findings provide a diagnostic test and suggest a model of autoimmune NMDAR-related encephalitis with broad implications for other immune-mediated disorders of memory, behavior, and cognition.

Topics & Keywords

Autoimmune Neurological Disorders and Treatments Neuroscience and Neuropharmacology Research RNA regulation and disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 61, Issue 1, pp. 25-36

DOI: 10.1002/ana.21050

Field-Weighted Citation Impact: 45.33