A Polymorphism in Toll‐Interleukin 1 Receptor Domain Containing Adaptor Protein Is Associated with Susceptibility to Meningeal Tuberculosis

2006173 citationsJournal Articlegreen Open Access

Authors

Thomas R. Hawn · University of Washington

Sarah J. Dunstan · Hospital for Tropical Diseases

Guy Thwaites · Hospital for Tropical Diseases

Cameron P. Simmons · University of Oxford

Nguyễn Thụy Thương Thương · Pham Ngoc Thach Hospital

Nguyễn Thị Ngọc Lan · Oxford University Clinical Research Unit

Hoang Thi Quy

Abstract

These results provide the first evidence of an association of a TIRAP SNP with the risk of any disease and also suggest that the Toll-like receptor pathway influences susceptibility to meningeal and pulmonary TB by different immune mechanisms.

Topics & Keywords

Immune Response and Inflammation Pneumonia and Respiratory Infections Bacterial Infections and Vaccines

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 194, Issue 8, pp. 1127-1134

DOI: 10.1086/507907

Field-Weighted Citation Impact: 5.25