Herpes Simplex Virus (HSV) Suppression with Valacyclovir Reduces Rectal and Blood Plasma HIV‐1 Levels in HIV‐1/HSV‐2–Seropositive Men: A Randomized, Double‐Blind, Placebo‐Controlled Crossover Trial

Valacyclovir significantly reduces rectal and plasma HIV-1 levels in HIV-1/HSV-2-coinfected men. HSV suppression may provide clinical benefits to persons not receiving highly active ART as well as public health benefits.