LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control

201465 citationsJournal Articlegreen Open Access

Authors

Mariana Vignoni · University of Ottawa

Hasitha de Alwis Weerasekera · University of Ottawa

Madeline J. Simpson · Centre for Catalysis Research and Innovation

Jaywant Phopase · Linköping University

Thien-Fah Mah · Bipar

May Griffith · Regenerative Medicine Institute

Emilio I. Alarcón

Abstract

Capping silver nanoparticles with LL37 peptide eradicates the antiproliferative effect of silver on primary skin cells, but retains the bactericidal properties of silver nanoparticles with activities comparable to silver nitrate or silver sulfadiazine. In addition, LL37 capped silver nanoparticles have anti-biofilm formation activity.

Topics & Keywords

Antimicrobial Peptides and Activities Antimicrobial agents and applications Polydiacetylene-based materials and applications

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Nanoscale

Volume 6, Issue 11, pp. 5725-5728

DOI: 10.1039/c4nr01284d

Field-Weighted Citation Impact: 4.43