Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

20121,935 citationsJournal Articlebronze Open Access

Authors

Jay P. Patel

Mithat Gönen

María E. Figueroa · Memorial Sloan Kettering Cancer Center

Hugo F. Fernández · Moffitt Cancer Center

Zhuoxin Sun · Dana-Farber Cancer Institute

Janis Racevskis · Montefiore Medical Center

Pieter Van Vlierberghe · Cancer Genetics (United States)

Igor Dolgalev

Abstract

We found that DNMT3A and NPM1 mutations and MLL translocations predicted an improved outcome with high-dose induction chemotherapy in patients with AML. These findings suggest that mutational profiling could potentially be used for risk stratification and to inform prognostic and therapeutic decisions regarding patients with AML. (Funded by the National Cancer Institute and others.).

Topics & Keywords

Acute Myeloid Leukemia Research Myeloproliferative Neoplasms: Diagnosis and Treatment Sarcoma Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 366, Issue 12, pp. 1079-1089

DOI: 10.1056/nejmoa1112304

Field-Weighted Citation Impact: 111.93