Fluorine in medicinal chemistry

20077,329 citationsReview

Authors

Peter R. Moore · AstraZeneca (United Kingdom)

Steve Swallow · AstraZeneca (United Kingdom)

Véronique Gouverneur · Oxford Research Group

Abstract

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

Topics & Keywords

Fluorine in Organic Chemistry Synthesis and Biological Evaluation Synthesis and Reactions of Organic Compounds

Publication Details

Published in: Chemical Society Reviews

Volume 37, Issue 2, pp. 320-330

DOI: 10.1039/b610213c

Field-Weighted Citation Impact: 51.95

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Fluorine in medicinal chemistry

Authors

Abstract

Topics & Keywords

Publication Details