TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis

2007412 citationsJournal Articlegold Open Access

Authors

Marco Prinz · Universitätsmedizin Göttingen

Harald Neumann · European Neuroscience Institute Göttingen

Abstract

Intravenously applied bone marrow-derived and TREM2-tranduced myeloid precursor cells limit tissue destruction and facilitate repair within the murine CNS by clearance of cellular debris during EAE. TREM2 is a new attractive target for promotion of repair and resolution of inflammation in multiple sclerosis and other neuroinflammatory diseases.

Topics & Keywords

Inflammation biomarkers and pathways Neuroinflammation and Neurodegeneration Mechanisms Autoimmune and Inflammatory Disorders Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 4, Issue 4, pp. e124-e124

DOI: 10.1371/journal.pmed.0040124

Field-Weighted Citation Impact: 6.20