Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis

2012298 citationsJournal Article

Authors

Richard Hansen · Royal Aberdeen Children's Hospital

Richard K. Russell · Royal Hospital for Children

Caroline Reiff · Max Planck Institute for Metabolism Research

Petra Louis · University of Aberdeen

Freda M. McIntosh · University of Aberdeen

Susan H. Berry · University of Aberdeen

Indrani Mukhopadhya

Abstract

Our results offer a comprehensive examination of the IBD mucosal microbiota at diagnosis, unaffected by therapeutic confounders or changes over time. Our results challenge the current model of a protective role for F. prausnitzii in CD, suggesting a more dynamic role for this organism than previously described.

Topics & Keywords

Inflammatory Bowel Disease Microscopic Colitis Clostridium difficile and Clostridium perfringens research

Publication Details

Published in: The American Journal of Gastroenterology

Volume 107, Issue 12, pp. 1913-1922

DOI: 10.1038/ajg.2012.335

Field-Weighted Citation Impact: 15.92

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Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis

Authors

Abstract

Topics & Keywords

Publication Details