Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy

2013189 citationsJournal Article

Authors

Yongchao Yang · Collaborative Innovation Center of Advanced Microstructures

Qiuli Guo · Collaborative Innovation Center of Advanced Microstructures

Huachao Chen · Collaborative Innovation Center of Advanced Microstructures

Zhikuan Zhou · Collaborative Innovation Center of Advanced Microstructures

Zijian Guo · Collaborative Innovation Center of Advanced Microstructures

Zhen Shen · Collaborative Innovation Center of Advanced Microstructures

Abstract

The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (ΦΔ = 0.63) and exhibits photocytotoxicity upon irradiation in the NIR region making it potentially suitable for use in PDT.

Topics & Keywords

Nanoplatforms for cancer theranostics Luminescence and Fluorescent Materials Photodynamic Therapy Research Studies

Publication Details

Published in: Chemical Communications

Volume 49, Issue 38, pp. 3940-3940

DOI: 10.1039/c3cc40746b

Field-Weighted Citation Impact: 13.30

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Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy

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Abstract

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Publication Details