Contralateral Breast Cancer in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers

2004618 citationsJournal Article

Authors

Kelly Metcalfe · Sunnybrook Health Science Centre

Henry T. Lynch · Sunnybrook Health Science Centre

Parviz Ghadirian · Sunnybrook Health Science Centre

Nadine Tung · Sunnybrook Health Science Centre

Ivo A. Olivotto · Sunnybrook Health Science Centre

Ellen Warner · Sunnybrook Health Science Centre

Olufunmilayo I. Olopade

Abstract

The risk of contralateral breast cancer in women with a BRCA mutation is approximately 40% at 10 years, and is reduced in women who take tamoxifen or who undergo an oophorectomy.

Topics & Keywords

BRCA gene mutations in cancer DNA Repair Mechanisms Genomic variations and chromosomal abnormalities

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 22, Issue 12, pp. 2328-2335

DOI: 10.1200/jco.2004.04.033

Field-Weighted Citation Impact: 22.91