Modulation of HIV-1 infectivity and cyclophilin A-dependence by Gag sequence and target cell type

200933 citationsJournal Articlegold Open Access

Authors

Denise Lecossier · Institut Universitaire de France

Abstract

Multiple interactions between host-cell factors and Gag can strongly affect HIV-1 infectivity, and these vary according to target cell type and the origin of the Gag sequence. Two of the cellular activities involved appear to be modulated in opposite directions by CypA-CA interactions, and Gag sequences determine the intrinsic sensitivity of a given virus to each of these cellular activities.

Topics & Keywords

HIV Research and Treatment Immune Cell Function and Interaction Signaling Pathways in Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Retrovirology

Volume 6, Issue 1, pp. 21-21

DOI: 10.1186/1742-4690-6-21

Field-Weighted Citation Impact: 1.20