Recombinant Leptin for Weight Loss in Obese and Lean Adults

19991,424 citationsJournal Article

Authors

Steven B. Heymsfield · St. Luke's-Roosevelt Hospital Center

Andrew S. Greenberg · Tufts University

Ken Fujioka · Scripps Clinic

Russell M. Dixon · University of Wisconsin–Madison

Robert F. Kushner

Thomas E. Hunt · Pharmac

John A. Lubina · Amgen (United States)

Abstract

A dose-response relationship with weight and fat loss was observed with subcutaneous recombinant leptin injections in both lean and obese subjects. Based on this study, administration of exogenous leptin appears to induce weight loss in some obese subjects with elevated endogenous serum leptin concentrations. Additional research into the potential role for leptin and related hormones in the treatment of human obesity is warranted.

Topics & Keywords

Regulation of Appetite and Obesity Biochemical Analysis and Sensing Techniques Adipokines, Inflammation, and Metabolic Diseases

Publication Details

Published in: JAMA

Volume 282, Issue 16, pp. 1568-1568

DOI: 10.1001/jama.282.16.1568

Field-Weighted Citation Impact: 20.63

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Recombinant Leptin for Weight Loss in Obese and Lean Adults

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Abstract

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Publication Details