Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia

2004337 citationsJournal Articlehybrid Open Access

Authors

Pierluigi Quadri · Ospedale Regionale di Mendrisio

C. Fragiacomo

Rita Pezzati

Enrica Zanda

Gianluigi Forloni · Mario Negri Institute for Pharmacological Research

Mauro Tettamanti · Mario Negri Institute for Pharmacological Research

Ugo Lucca · Mario Negri Institute for Pharmacological Research

Abstract

These findings suggest that relative folate deficiency may precede AD and VaD onset. Hyperhomocysteinemia might also be an early risk factor for cognitive decline in the elderly, but its role in dementia development must be addressed in future longitudinal studies.

Topics & Keywords

Folate and B Vitamins Research Esophageal and GI Pathology Fluoride Effects and Removal

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Clinical Nutrition

Volume 80, Issue 1, pp. 114-122

DOI: 10.1093/ajcn/80.1.114

Field-Weighted Citation Impact: 14.02