Broadly Protective Protein-Based Pneumococcal Vaccine Composed of Pneumolysin Toxoid–CbpA Peptide Recombinant Fusion Protein

201386 citationsJournal Article

Authors

Beth Mann

Justin A. Thornton · Office of Infectious Diseases

Richard J. Heath · St. Jude Children's Research Hospital

Kristin R. Wade · University of Oklahoma Health Sciences Center

Rodney K. Tweten · University of Oklahoma Health Sciences Center

Geli Gao · Office of Infectious Diseases

Karim El Kasmi · Office of Infectious Diseases

Abstract

The CbpA peptide-L460D pneumolysoid fusion protein was broadly protective against pneumococcal infection, with the potential for additional protection against other meningeal pathogens.

Topics & Keywords

Pneumonia and Respiratory Infections Bacterial Infections and Vaccines Respiratory viral infections research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 209, Issue 7, pp. 1116-1125

DOI: 10.1093/infdis/jit502

Field-Weighted Citation Impact: 6.31